TYK2 (tyrosine kinase 2) is a protein-coding gene. The encoded protein, tyrosine kinase 2, interacts with the cytoplasmic domain of type I and type II cytokine receptors and mediates cytokine signaling by phosphorylating receptor subunits. It is also a component of the type I and type III interferon signaling pathways and is thought to play a role in antiviral immunity.
TYK2 gene
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The receptor protein tyrosine kinases possess a transmembrane domain and belong to a large and diverse multigene family. In the human genome, 58 receptor-type protein tyrosine kinases have been identified, distributed among 20 subfamilies. Mutations in the TYK2 gene have been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Signaling pathways in this gene family include interleukin-1 signaling pathways.
Gene Ontology (GO) annotations associated with this gene include transferase activity, phosphorus-containing group transfer, and protein tyrosine kinase activity. An important paralog of this gene is JAK1.