TRPC

Last updated on: 18.12.2020

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DefinitionThis section has been translated automatically.

TRPC is the acronym for "Transient Receptor Potential Cation Channel, Subfamily C". TRPCs represent a group of receptor-driven, calcium-permeable, non-selective cation channels of the TRP superfamily. Structurally, members of this family possess a number of similar features, including 3 or 4 ankyrin repeats near the N-terminus and a TRP box motif at the proximal C-terminus. Cryogenic electron microscopy was used to construct several high-resolution structures of TRPC channels with 3-D representations of the channel structures.

The channels are permeable to cations and contribute to a wide range of cellular functions and physiological roles. Their regulations have been shown to involve multiple components of the phospholipase C pathway, Gi and Go proteins, and internal Ca2+ stores. In general, TRPC channels can be activated by phospholipase C stimulation, although some members can also be activated by diacylglycerol.

TRPC 1,4 and 5 are activated by the metabotropic glutamate receptor 1 agonist dihydroxyphenylglycine. TRPC1 also by stretching cell membranes.

ClassificationThis section has been translated automatically.

The seven TRPC members can be divided into four subgroups based on their amino acid sequences and functional similarities:

PathophysiologyThis section has been translated automatically.

Role in cardiomyopathies: TRPC1 channels are found on cardiomyocytes, smooth muscle and endothelial cells (Rowell J et al. 2010). Up-regulation of TRPC1, TRPC3 and TRPC6 genes is observed in fibrotic heart disease as well as cardiovascular disease. TRPC channels are suspected to respond to an overload of hormonal and mechanical stimulation in cardiovascular disease and contribute to pathological remodelling of the heart (Rowell J et al. 2010). Apparently, TRPC1, TRPC3 and TRPC6 channels promote cardiac hypertrophy via activation of the calcineurin pathway and the downstream transcription factor nuclear factor of activated T cells (NFAT). In any case, deletion of the TRPC1 gene led to decreased hypertrophy in animal experiments when stimulated with hypertrophic stimuli. (Rowell J et al 2010). TRPC3 is upregulated in the atria of patients with atrial fibrillation (AF). Simultaneously, TRPC3 regulates angiotensin II-induced cardiac hypertrophy, which contributes to fibroblast formation. Blockade of TRPC3 results in a decrease in fibroblast formation and reduced susceptibility to AF.

There is strong evidence for the pathogenetic significance of mutations in the TRPC6 gene for familial focal segmental glomerulosclerosis.

Dysfunction of TRPC6 also seems to play a role in Alzheimer's disease (Lessard CB et al. 2005; Winn M P et al. 2005).

Note(s)This section has been translated automatically.

The involvement of the TRPC channel in well-studied signaling pathways and its importance in the impact of genes on human disease make it a potential target for drug therapy (Moran M et al. 2011).

LiteratureThis section has been translated automatically.

  1. Boulay G et al. (1999) Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci. U.S.A. 96: 14955-14960
  2. Fowler MA et al (2007) Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS ONE 2: e573.
  3. Lessard CB et al (2005) The overexpression of presenilin2 and Alzheimer's disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells. Cell Signal 17: 437-445.
  4. Nilius B et al (2011) The transient receptor potential family of ion channels. Genome Biol 12:218.
  5. Nilius B et al. 2007). Transient receptor potential cation channels in disease. Physiol Rev 87: 165-217.
  6. Rowell J et al. (2010) TRP-ing up heart and vessels: canonical transient receptor potentials and cardiovascular disease. Journal of Cardiovascular Translational Research3: 516-524.
  7. Tang Q et al. (2018) Structure of the receptor-activated human TRPC6 and TRPC3 ion channels. Cell Research 28: 746-755

  8. Winn M P et al (2005) A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801-1804

Last updated on: 18.12.2020