STAT5A (Signal Transducer And Activator Of Transcription 5A) is a protein coding gene located on chromosome 17q21.2. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and then form homo- or heterodimers that translocate to the nucleus where they act as transcriptional activators.
STAT5A-gene
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General informationThis section has been translated automatically.
STA5B is activated by many cell ligands such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin and various growth hormones and mediates their responses. Activation of this protein in myeloma and lymphoma associated with TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumor induction.
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Diseases associated with STAT5A include chronic leukemia and polycythaemia vera.
Related pathways include the ERK pathway and the Brain-Derived Neurotrophic Factor (BDNF) pathway. An important paralog of this gene is STAT5B.
LiteratureThis section has been translated automatically.
- Bachmann J et al. (2011) Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Bio 7:516.
- Heltemes-Harris LM et al (2012) The role of STAT5 in lymphocyte development and transformation. Curr. Opin. Immunol 24:146-152.
- Rawlings JS et al (2004) The JAK/STAT signaling pathway. . Cell Sci 117:1281-1283.
- Yamaoka K et al (2004) The Janus kinases (Jaks) Genome Biol5:253.