The SH3 domain is a small protein domain of about 60 amino acid residues that mediates specific protein interactions. The abbreviation SH3 stands forSRC-homology 3 domain(Src-homology 3) derived from the protein kinase C-Src, in which the domain was first described.
SH3-domain
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
Originally, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk (see Crk protein below). The SH3 domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src.
SH3 domains are found in proteins of signaling pathways that regulate the cytoskeleton, the Ras protein and Src kinase, and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. When interacting with tyrosine kinases, the SH3 proteins usually bind far from the active site.
In addition, the SH3 domain is responsible for controlling protein-protein interactions in signal transduction pathways and regulating the interactions of proteins involved in cytoplasmic signal transduction.
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Proteins in which the SH3 domain is present:
- Signal transducing adaptor proteins
- CDC24
- Cdc25
- PI3 kinase
- Phospholipase
- Ras GTPase-activating protein
- Vav proto-oncogene
- GRB2
- p54 S6 kinase 2 (S6K2)
- SH3D21
- ARMH3 (potentially)
- STAC3
- Some myosins
- SH3 and multiple ankyrin repeat domains: SHANK1, SHANK2, SHANK3
- YAP1
- ARHGAP12
- vexin (VXN)
- TANGO1
- Integrase
- Focal adhesion kinase (FAK, PTK2)
- Proline-rich tyrosine kinase (Pyk2, CADTK, PTK2beta)
- TRIP10 (cip4)