PCM1 Gene

Last updated on: 27.10.2021

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DefinitionThis section has been translated automatically.

PCM1 gene (PCM is the acronym for "Pericentriolar Material 1") refers to a protein-coding gene localized on chromosome 8p22. The protein encoded by this gene is a component of the centriolar satellites, i.e. the electron-dense granules localized around the centrosomes.

General informationThis section has been translated automatically.

This protein has been shown to be essential for the correct localization of several centrosomal proteins and for the anchoring of microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a number of hematological malignancies , including atypicalchronic myeloid leukemia and T-cell lymphomas (Reiter A et al. 2017).

Several transcript variants encoding different isoforms have been found for this gene.

LiteratureThis section has been translated automatically.

  1. Reiter A et al (2017) Myeloid neoplasms with eosinophilia. Blood129:704-714.

Last updated on: 27.10.2021