NovaSeq (the name stands for: "Nova" - new - "Seq" for sequencing) is the name for the currently most powerful generation of DNA sequencing devices from Illumina for "Next Generation Sequencing (NGS)". It is optimized for maximum data volumes at minimum cost per base. NovaSeq is a platform for ultra-high-throughput sequencing that has been specially developed for very large genomic projects.
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NovaSeq
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
Newer Illumina® platforms such as the NovaSeq and NextSeq series significantly outperform older sequencers in terms of reads, performance and runtime. Such protocols allow multiplexing of thousands of samples in a single run with a read depth of tens of millions of sequences per sample (Flörl L et al. 2026).
NovaSeq uses:
- novel patterned flow cells
- improved cluster density
- optimized imaging
- automated fluidics
- modular S, S-Prime and SP/XP run modes
This allows the system to be flexibly adapted to small or large projects. NovaSeq is today's gold standard for large-scale sequencing projects.
LiteratureThis section has been translated automatically.
- Flörl L et al. (2026) HighALPS: ultra-high-throughput marker-gene amplicon library preparation and sequencing on the Illumina NextSeq and NovaSeq Platforms. mSystems 10:e0002326.