NAMPT (nicotinamide phosphoribosyltransferase) is a protein-coding gene located on chromosome 7q22.3.
NAMPT gene
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
The NAMPT gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to form nicotinamide mononucleotide, a step in the biosynthesis of nicotinamide adenine dinucleotide. The encoded protein, called visfatin, belongs to the family of nicotinic acid phosphoribosyltransferases (NAPRTases) and is thought to be involved in many important biological processes, including metabolism, stress response and aging. The NAMPT gene has a pseudogene on chromosome 10 and an important paralog of this gene is NAPRT.
PathophysiologyThis section has been translated automatically.
Diseases associated with NAMPT include "ageing" and gestational diabetes. Associated metabolic pathways include NAD metabolism and gene expression (transcription).
The encoded protein(visfatin) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to form nicotinamide mononucleotide, an intermediate of NAD biosynthesis. It is the rate-determining component in the mammalian NAD biosynthetic pathway.
The secreted form behaves both as a cytokine with immunomodulatory properties and as an adipokine with antidiabetic properties. It has no enzymatic activity, partly due to the lack of activation by ATP, which is only present in small amounts in the extracellular space and plasma.
LiteratureThis section has been translated automatically.
- Kanda N et al. (2011) Visfatin enhances CXCL8, CXCL10, and CCL20 production in human keratinocytes. Endocrinology. 152:3155-3164).
- Mohammadi M et al. (2019) Circulating visfatin levels and cancers risk: A systematic review and meta-analysis. J Cell Physiol 234:5011-5022.
- Sonoli SS et al (2011) Visfatin--a review. Eur Rev Med Pharmacol Sci 15:9-14.