MSC Gene

Last updated on: 01.12.2021

Dieser Artikel auf Deutsch

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

MSC (Musculin) is a protein coding gene located on chromosome 8q13.3. The protein encoded by this gene is a transcriptional repressor that can bind an E-box element in vitro either as a homodimer or as a heterodimer with E2A. This protein complex is capable of inhibiting the transactivation ability of E47, an E2A protein, in mammalian cells.

Note(s)This section has been translated automatically.

Diseases associated with MSC include:

  • Alk-negative anaplastic large cell lymphoma

and

  • rhabdomyosarcoma.

LiteratureThis section has been translated automatically.

  1. Buchanan RM et al (2011) B-cell activating factor (BAFF) promotes CpG ODN-induced B cell activation and proliferation. Cell Immunol 271:16-28.
  2. Coffman RL et al (1986) B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol 136:4538-4541.

Last updated on: 01.12.2021