Significant organ manifestation of systemic lupus erythematosus (SLE), occurs in > 40 % of patients. Important role in mortality and morbidity of SLE, approx. 30 % do not respond to therapy, in many cases the response is delayed!
Typical representative of immune complex glomerulonephritis with deposition of mesangial and sub-endothelial immune complexes (especially DNA/anti-DNA complexes)
Multiple glomerular lesions
Variable clinical and laboratory signs
Association with anti-ds-DNA antibodies