LCE1A gene

Last updated on: 24.01.2026

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DefinitionThis section has been translated automatically.

The LCE1A gene (LCE1A stands for "Late Cornified Envelope 1A") is a protein-coding gene located on chromosome 1q21.3. The associated signaling pathways include keratinization and development of the nervous system

General informationThis section has been translated automatically.

LCE1A belongs to the late cornified envelope protein (LCE) gene cluster located within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains several conserved genes that encode proteins of the stratum corneum. These genes are expressed relatively late (late cornified envelope proteins) during fetal formation of the cornified envelope of the skin

Diseases associated with LCE1A include cataract 31.

LiteratureThis section has been translated automatically.

  1. Mathyer ME et al. (2021) Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa. Nat Commun 12:2557.
  2. Tanaka Y et al. (2023) Up-Regulated Expression of ICAM1, MT1A, PTGS2, LCE3D, PPARD, and GM-CSF2 Following Solar Skincare Protection and Repair Strategies in a 3-Dimensional Reconstructed Human Skin Model. Clin Cosmet Investig Dermatol16:2829-2839.

Last updated on: 24.01.2026