The IRAK2 gene (IRAK2 stands for: Interleukin 1 Receptor Associated Kinase 2) is a protein coding gene located on chromsome 3p25.3. The IRAK2 gene encodes interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to be involved in IL1-induced upregulation of NF-kappaB.
IRAK2 gene
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The interleukin-1 receptor-associated kinases are serine-threonine kinases, EC 2.7.11.1, which are key regulators of IL-1R and TLR-mediated signaling. To date, four IRAK isoforms have been identified: IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4.
Related signaling pathways include the MyD88-dependent cascade initiated at the endosome and the Toll Comparative Pathway. An important paralog of this gene is IRAK1. The eponymous protein IRAK2, encoded by the IRAK2 gene, binds to the IL-1 type I receptor upon IL-1 engagement and triggers intracellular signaling cascades that lead to transcriptional upregulation and mRNA stabilization.
LiteratureThis section has been translated automatically.
- Boumiza A et al. (2020) IRAK2 is associated with systemic lupus erythematosus risk. Clin Rheumatol 39:419-424.
- Hassine HB et al. (2018) IRAK2 is associated with susceptibility to rheumatoid arthritis. Clin Rheumatol 37):927-933.
- Shao S et al. (2021) IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses. J Invest Dermatol 141:2436-2448.