Interleukin-1 receptor antagonist

Last updated on: 19.01.2024

Dieser Artikel auf Deutsch

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

The interleukin-1 receptor antagonist is a member of the interleukin-1 cytokine family. The cytokine is encoded by the IL1RN gene, which is located on chromosome 2q14.1 The interleukin-1 receptor antagonist inhibits the activity of interleukin-1 by binding to its receptor(IL1R1) and thus preventing its association with the co-receptor IL1RAP for signal transmission. The interleukin-1 receptor antagonist thus inhibits the activities of interleukin-1 alpha (IL-1alpha) and interleukin-1beta (IL-1beta) and modulates a variety of interleukin-1-related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. Several alternatively spliced transcript variants encoding different isoforms are known.

LiteratureThis section has been translated automatically.

  1. Aksentijevich I et al. (2009) An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. New Eng J Med 360: 2426-2437.
  2. Ivker RA et al. (1993) Infantile generalized pustular psoriasis associated with lytic lesions of the bone. Pediat Derm 10: 277-282.
  3. Leung VC et al. (1985) Infantile cortical hyperostosis with intramedullary lesions. J Pediat Orthop 5354-5357.
  4. Reddy S et al. (2009) An autoinflammatory disease due to homozygous deletion of the IL1RN locus. New Eng J Med 360: 2438-2444.
  5. Sofman MS et al (1990) Dermatoses associated with sterile lytic bone lesions. J Am Acad Derm 23: 494-498.

Last updated on: 19.01.2024