Hyperplastic polyposis syndromeD12.6
Synonym(s)
DefinitionThis section has been translated automatically.
Rare, mostly sporadic, hitherto less well researched clinical picture associated with a significant risk of colon cancer (about 30% of patients in the collectives studied had colon cancer at initial diagnosis).
EtiopathogenesisThis section has been translated automatically.
The genetic causes of hyperplastic polyposis are still unknown.
LocalizationThis section has been translated automatically.
Preferably in the right colon above the sigmoid colon.
DiagnosisThis section has been translated automatically.
Diagnostic criteria (WHO) are currently > 30 or large hyperplastic polyps (at least 2 of 5 polyps > 1.0 cm). Evidence of hyperplastic polyposis in a first degree relative.
Differential diagnosisThis section has been translated automatically.
MUTYH-associated polyposis (MAP) .
General therapyThis section has been translated automatically.
If the number of polyps remains low, endoscopic polypectomy is the therapeutic gold standard. Because of the risk of carcinoma and a further extension of the polyposis, surgical intervention of a colectomy with proctectomy and ileo-anal anastomosis can also be recommended.
Note(s)This section has been translated automatically.
The term hyperplastic polyps or serrated polyps today includes hyperplastic polyps in the narrower sense as well as sessile serrated adenomas and traditional serrated adenomas and mixed forms.
In the hyperplastic polyposis syndrome the occurrence of sessile serratified adenomas is typical. According to the current pathogenetic understanding, these have the highest potential for carcinoma development (serratated route of colon carcinogenesis).