The HTR3A gene (HTR3A stands for: 5-hydroxytryptamine receptor 3A) is a protein-coding gene located on chromosome 11q23.2. Alternatively spliced transcript variants coding for different isoforms have been identified.
HTR3A gene
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The HTR3A gene codes for a receptor protein that belongs to the superfamily of ligand-gated ion channel receptors. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel.
The HTR3A gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that acts as a neurotransmitter, hormone and mitogen. The encoded receptor protein forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes that elicit rapid, depolarizing responses in neurons upon activation. It appears that the heteromeric combination of A and B subunits is necessary to obtain the full functional properties of this receptor, as each subunit alone results in receptors with very low conductance and response amplitude.
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Diseases associated with HTR3A include serotonin syndrome and irritable bowel syndrome.
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To date, five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).
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- Gu QY et al. (2015) Association of genetic polymorphisms in HTR3A and HTR3E with diarrhea predominant irritable bowel syndrome. Int J Clin Exp Med 8:4581-4585.
- Suchanecka A et al. (2022) Serotonin Receptor HTR3A Gene Polymorphisms rs1985242 and rs1062613, E-Cigarette Use and Personality. Int J Environ Res Public Health 19:4746.