Holohaptocorrin (HoloHC) is a vitamin B 12 (cobalamin) bound to haptocorrin. Haptocorrin itself is a transport protein for vitamin B 12 (Herold 2018).
Holohaptocorrin
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
The standard value for HoloHC is > 180 pg / ml (Herold 2018).
A vitamin B 12 deficiency can be diagnosed at a very early stage by a drop in holoHC (Schmidt 2022).
OccurrenceThis section has been translated automatically.
Around 80 % of plasma cobalamin is bound to haptocorrin and is present as holoHC (Schmidt 2022).
PathophysiologyThis section has been translated automatically.
In the stomach, vitamin B12 ingested with food and bound to dietary protein is released by the action of gastric acid and then bound to haptocorrin. This so-called holohaptocorrin is also broken down by the addition of pancreatic enzymes and the alkaline pH value in the upper section of the small intestine. Vitamin B 12 is then bound to the instrinsic factor, which is formed in the gastric mucosa, and finally absorbed cellularly in the lower ileum (Herold 2018).
LiteratureThis section has been translated automatically.
- Herold G et al. (2018) Internal medicine. Herold Publishing House 38 - 40
- Kasper D L, Fauci A S, Hauser S L, Longo D L, Jameson J L, Loscalzo J et al. (2015) Harrison's Principles of Internal Medicine. Mc Graw Hill Education 640
- Schmidt N, Schmidt E (2022) Micronutrient therapy. Elsevier Urban and Fischer Publishers Germany 266