Various grading systems exist to assess the chronicity of glomerulonephritis (Sethi 2019):
- Standardized grading of chronic changes in the kidney (Sethi 201).
- Global and segmental glomerulosclerosis (GS) are graded from 0 to 3
- Tubule shrinkage with thickening of tubular basement membrane and flattening of tubular epithelium (TA) scored 0 to 3
- Interstitial fibrosis (IF) with 0 to 3
- Arteriosclerosis with 0 to 1
Scores are summed (total renal chronicity score) to classify the overall severity of chronic lesions into minimal (0 - 1 total score), mild (2 - 4 total score), moderate (5 - 7 total score), and severe (≥ 8 total score)
(Sethi 2017)
- Oxford classification of IgA nephropathy (Sethi 2019):
Here, four variables are required for predicting renal outcome:
(1) the mesangial hypercellularity score
(2) segmental glomerulosclerosis
(3) endocapillary hypercellularity
(4) tubular atrophy/interstitial fibrosis (Roberts 2009).
- Modified International Society of Nephrology / Renal Pathology Society classification of lupus nephritis (Sethi 2019):
This classifies glomerular lesions into classes I - IV (Bajema 2018).
- Berden- Classification for ANCA associated glomerulonephritis (Sethi 2019):
This classification system divides biopsies into 4 different categories (Berden 2010).