Gangliosides are complex sphingolipids and components of the cell membrane in the central and peripheral nervous system that help determine its properties. They consist of a lipid, an oligosaccharide chain and N-acetylneuraminic acids. The individual gangliosides differ from each other in position and number of acids. Gangliosides occur in the central nervous system as well as in peripheral nerves.
Gangliosid antibodies
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Clarification of immune neuropathies
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Test material: 2 ml serum
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GM1 antibodies may be present in the following disorders:
- Miller-Fisher syndrome
- Guillain-Barré syndrome
- Paraproteinemic neuropathy
- Motor neuropathy,
- Motor multifocal neuropathy
- Chronic inflammatory demyelinating polyradiculopathy (CIDP)
- Diabetic neuropathy,
- Amyotrophic lateral sclerosis
- SLE
- Multiple Sclerosis
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Structural relationships are also found in various microorganisms. Microorganisms. Thus, the frequent occurrence of immune neuropathies after certain infections (e.g. Campylobacter jejuni, cytomegalovirus, Mycoplasma pneumoniae or Epstein-Barr virus -HHV4) is explained by a cross-reaction.
LiteratureThis section has been translated automatically.
- Uncini A (2012) A common mechanism and a new categorization for anti-ganglioside antibody-mediated neuropathies. Experimental Neurology 235:513-516.
- Yanagisawa K (2011) Pathological significance of ganglioside clusters in Alzheimer's disease. Journal of Neurochemistry 116:806-812.
- Wang B (2009) Sialic acid is an essential nutrient for brain development and cognition. Annual Review of Nutrition 29:177-222.