FGF6 gene

Last updated on: 11.11.2023

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DefinitionThis section has been translated automatically.

The FGF6 gene (FGF6 stands for: Fibroblast Growth Factor 6) is a protein-coding gene on chromosome 12p13.32.

General informationThis section has been translated automatically.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members have broad mitogenic and cellular survival activity and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The FGF6 gene exhibits oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene has a restricted expression profile, particularly in the myogenic lineage, suggesting a role in muscle regeneration or differentiation.

Annotations associated with this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF4.

Note(s)This section has been translated automatically.

Diseases associated with FGF7 include Apert syndrome and hyperphosphataemia.

LiteratureThis section has been translated automatically.

  1. Ågren MS et al. (2022) Gene Expression Linked to Reepithelialization of Human Skin Wounds. Int J Mol Sci 23:15746.
  2. Coulier F et al. (1991) The FGF6 gene within the FGF multigene family. Ann N Y Acad Sci 638:53-61
  3. Dong H et al. (2021) Integrated bioinformatic analysis reveals the underlying molecular mechanism of and potential drugs for pulmonary arterial hypertension. Aging (Albany NY) 13:14234-14257.

Last updated on: 11.11.2023