FGA Gene

Last updated on: 11.08.2023

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DefinitionThis section has been translated automatically.

The FGA gene (FGA stands for "fibrinogen alpha chain") is a protein-coding gene located on chromosome 4q31.3. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing.

General informationThis section has been translated automatically.

The FGA gene encodes the alpha subunit of the clotting factor fibrinogen. Following vascular injury, the encoded preprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin.

Mutations in this gene lead to various diseases, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and predominantly renal systemic amyloidosis (AFib amyloidosis - see also hereditary amyloidoses).

LiteratureThis section has been translated automatically.

  1. Ceglarz K et al (2023) Difficulties in the Diagnosis of Fibrinogen Aα-Chain Amyloidosis-Literature Review and Case Report of a Patient After Kidney Transplantation. Transplant Proc 55: 644-648.
  2. Mousson C et al (2006) Successful hepatorenal transplantation in hereditary amyloidosis caused by a frame-shift mutation in fibrinogen Aalpha-chain gene. Am J Transplant 6:632-635.
  3. Picken MM (2020) The pathology of amyloidosis in classification: A review. Acta Haematol 143:322-334.
  4. Yazaki M et al (2018) Hereditary fibrinogen Aα-chain amyloidosis in Asia: Clinical and Molecular Characteristics. Int J Mol Sci 19:320.

Last updated on: 11.08.2023