Synonyms
Thin basement membrane disease; TBMD; thin basement membrane disease; thin basement membrane nephropathy; thin basement membrane disease; TBMN; nephropathy with thin glomerular basement membrane; benign familial hematuria; type IV collagen-associated nephropathy;
First described
In 1966, McConville and McAdams were the first to describe a group of children with micro-hematuria that also affected other family members. Typically, however, they were not found to have nephropathy. They were the first to coin the term "benign familial hematuria." With the advent of electron microscopy in the 1970s, changes in the glomerular basement membrane could be described in this clinical picture (Plenova 2017).
After the 1970s, the term "thin membrane syndrome" was introduced (Plenova 2017).
In 2018, the following diagnoses were grouped under the umbrella term of "type IV associated disorders":
- benign familial hematuria
- thin basement membrane syndrome
- classic Alport syndrome (Brunkhorst 2021)