Akroynm for "rRNA adenine N-6-methyltransferase". This enzyme induces a demethylation of the adenine residue at position 2085 in 23S-rRNA in Staphylococcus aureus, which leads to a reduced affinity between ribosomes and the various macrolide antibiotics. macrolide antibiotics. The corresponding resistance gene with the same name is located on an R-plasmid of Staphylococcus aureus.