CORO1A (Coronin 1A) is a protein coding gene located on chromosome 16p11. CORO1A encodes a member of the WD repeat protein family. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
CORO1A Gene
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WD repeats are minimally conserved regions of approximately 40 amino acids typically characterized by Gly-His and Trp-Asp (GH-WD) that may facilitate the formation of heterotrimeric or multiprotein complexes.
The encoded protein may form a critical component of the cytoskeleton of highly motile cells involved in both the invagination of large portions of the plasma membrane and the formation of plasma membrane protrusions involved in cell locomotion. In mycobacteria-infected cells, retention of the protein at the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Diseases associated with CORO1A include immunodeficiency 8 syndrome.