Ceftriaxone
DefinitionThis section has been translated automatically.
Broad-spectrum cefalosporin of the 3rd generation.
Half-lifeThis section has been translated automatically.
6–9 h
Spectrum of actionThis section has been translated automatically.
Aeromonas hydrophilia, Capnocytophaga spp., Borrelia burgdorferi, Citrobacter spp., Clostridium perfringens, Enterobacter spp., E. coli, Hafnia alvei, Haemophilus spp., Klebsiella spp., Moraxella spp., Morganella morganii, Neisseria spp, Pasteurella multocida, Peptostreptococcus spp., Plesiomonas shigelloides, Prevotella spp., Proteus spp., Providencia spp., Salmonella spp., Serratia spp., Shigella spp., Staphylococcus spp., Streptococcus spp., Treponema pallidum, Yersinia spp.
IndicationThis section has been translated automatically.
Severe, life-threatening respiratory tract, urinary tract, skin, soft tissue, bone and joint infections. Therapy of acute neuroborreliosis, gonorrhoea, syphilis.
Dosage and method of useThis section has been translated automatically.
- Once 1-2 g/day i.v. (max. 4 g/day).
- Children: 20-80 mg/kg bw/day.
- Lyme disease: once 2 g/day for 2-4 weeks.
- Syphilis: 1 time 1 g/day i.v. over 10 days
- Gonorrhoea: 1.0 g i.v./i.m. as ED. To the i.m. administration 1.0 g ceftriaxone powder is dissolved in 4 ml 1% lidocaine hydrochloride. Injection in 1 or 2 portions (right (left) deep intragluteal. Lidocaine must not be administered intravenously.
PreparationsThis section has been translated automatically.
Rocephin, ceftriaxon-ratiopharm
Note(s)This section has been translated automatically.
- Little or no effectiveness against staphylococci
- Ineffective against listeria (meningitis!)
- For life-threatening infections combination therapy is possible (aminoglycoside, clindamycin, metronidazole)
LiteratureThis section has been translated automatically.
- Li RC et al (2004) Protein binding and antimicrobial activity of ceftriaxone: comparative assessments by gradient plate technique and time-kill study. J Chemother 16: 524-549