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Carboplatinum
Synonym(s)
Carboplatinum
DefinitionThis section has been translated automatically.
Platinum derivative of the second generation with alkylating effect on the DNA of tumour cells ( alkylans) for use as a cytostatic drug.
Pharmacodynamics (Effect)This section has been translated automatically.
Intracellular activation to release reactive platinum complexes. Binding to nucleophilic groups e.g. GC-rich DNA sequences. This creates DNA cross-links and DNA-protein links that lead to apoptosis and cell growth inhibition.
IndicationThis section has been translated automatically.
Approved for the treatment of advanced epithelial ovarian cancer and small cell lung cancer.
Malignant melanoma ( off-label use).
Pregnancy/nursing periodThis section has been translated automatically.
Contraindicated.
Dosage and method of useThis section has been translated automatically.
400 mg/m2 KO i.v. as infusion over 15-60 minutes.
Undesirable effectsThis section has been translated automatically.
Systemic ADRs:
- Thrombocytopenia and other blood formation disorders
- gastrointestinal disorders
- Toxic liver damage
- Renal damage
- Cardiac arrhythmia
- neurological disorders, visual, hearing and taste disorders
- Disorders of spermatogenesis and ovulation.
Cutaneous ADRs (listed according to their frequency):
- Alopecia
- Pruritus
- Exantheme
- Stomatitis(mucositis)
- allergic reactions up to anaphylactic shock
- Stevens-Johnson syndrome
- Raynaud's Syndrome
- Skin necroses after intra-arterial application.
PreparationsThis section has been translated automatically.
Carboplatinum Hexal®, Carboplatinum ratiopharm®