In addition to the BOT, there is also a special form, the so-called BOT plus.
It is a successor scheme of the BOT. It is used when the BOT setting is no longer sufficient. At the same time, it is also a precursor of conventional insulin therapy.
In BOT plus, a short-acting insulin is injected before the problem meal (meal with the highest p.p. blood glucose) in addition to the long-acting insulin. The dose is usually 20% of the dose of the long-acting insulin.
The advantages of BOT- plus are:
- more balanced daily profile
- low rate of hypoglycemia
- suitable for "top-up" with short-acting insulin analogues if it is unclear how much will be eaten.
(Berthold 2021)