The ARPC1B gene (ARPC1B stands for "Actin Related Protein 2/3 Complex Subunit 1B") is a protein coding gene located on chromosome 7q22.1.
The ARPC1B gene encodes one of the seven subunits of the human Arp2/3 protein complex. This subunit belongs to the SOP2 family of proteins. It is likely that a second protein encoded by the ARPC1A gene functions with it as the p41 subunit of the human Arp2/3 complex, a multiprotein complex that mediates actin polymerization after stimulation by nucleation-promoting factor (NPF). It is likely that the complex also plays a role in centrosomal homeostasis, being an activator and substrate of Aurora A kinase.
In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting actin polymerization in the nucleus to drive the mobility of double-strand breaks (DSBs).