Angiotensinogen

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

HistoryThis section has been translated automatically.

Ohkubo et al. 1983

DefinitionThis section has been translated automatically.

Angiotensinogen is a protein, a prohormone with 452 amino acids with a molecular weight of 49,761 Da. The coding gene is located on the long arm of chromosome 1 (Chr 1: 228.9 - 228.92 ). After translation by hepatocytes and transport to the liver cell membrane, the peptide angiotensin I , which consists of 10 amino acids, is cleaved off, the actual effective signal sequence. The resulting angiotensinogen is released into the plasma.

General informationThis section has been translated automatically.

The angiotensinogen formed in the liver circulates in human blood plasma. During the electrophoretic separation of serum proteins, it migrates in the α2 globulin fraction.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer