Images (2)
Anastrozole
Synonym(s)
DefinitionThis section has been translated automatically.
Anastrozole is an orally administrable active substance (mean half-life: approx. 45.0 h) from the group of non-steroidal aromatase inhibitors. By blocking the aromatases, the remaining estrogen production in and after menopause decreases again significantly. A single dose of 1 mg already reduces estrogen levels by 70% in 7 days and by up to 80% within 14 days. In addition, anastrozole directly inhibits aromatase in tumor cells. And thus limits the growth and spread of tumor cells.
Anastrozole has no progestogenic, androgenic or estrogenic effect.
IndicationThis section has been translated automatically.
Advanced or metastatic breast cancer in postmenopausal patients.
Undesirable effectsThis section has been translated automatically.
hot flushes, flush
Tiredness
Headaches
Nausea
Depressions
Insomnia
cholesterol decline
Osteoporosis
Skin changes rarely (see aromatase inhibitors below)
PreparationsThis section has been translated automatically.
Arimidex®
Anablock® 1 mg Film coated tablets
AnastroHEXAL® 1 mg Film coated tablets
Note(s)This section has been translated automatically.
The performance-enhancing effect of anastrozole in female athletes is explained by its estrogen-reducing effect. For example, when the concentration of oestrogen decreases, less water and less fat is stored in the body. This provides female athletes with weight advantages, for example.
LiteratureThis section has been translated automatically.
- Coates AS et al (2014) Tailoring therapies-improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer Robert Koch-Institute Ann Oncol 26: 1533-1546
- Cuzick J et al (2010) Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol 11: 1135-1141
- Goss PE (1999) Risks versus benefits in the clinical application of aromatase inhibitors. Endocr Relat Cancer 6: 325-32
Kim YJ et al (2020) Anastrozole-Induced Dermatitis: Report of a Woman with an Anastrozole-Associated Dermatosis and a Review of Aromatase Inhibitor-Related Cutaneous Adverse Events. Dermatol Ther (Heidelberg) 10:221-229.