Ama

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

Synonym(s)

Antibodies antimitochondrial; Antimitochondrial antibodies

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DefinitionThis section has been translated automatically.

Acronym for "antimitochondrial antibodies" (autoantibodies against mitochondria). 9 subtypes against different mitochondrial AK (M1-M9) are known.

IndicationThis section has been translated automatically.

AMA titers are particularly elevated in primary biliary cirrhosis (Ak against M2: specificity: approx. 95%), in systemic scleroderma, CREST syndrome, polymyositis.

Increased titers are less frequent in antiphospholipid syndrome and lupus erythematosus .

An increase in AMA titre is also possible in syphilis II.

ImplementationThis section has been translated automatically.

Determination method:

IFT (Hep-2 cells) or prox. renal tubules.

ELISA: quatitaver detection

Immunoblot: Differentiation of the subunits M1-M9

Note(s)This section has been translated automatically.

Determination from blood serum (blood sample required to obtain 5 ml serum). Standard value: titre < 1:10.
In unclear cases, have AMA subtyping performed.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer