Alpha1-microglobulin$$
Synonym(s)
DefinitionThis section has been translated automatically.
Alpha1 microglobulin, also known as protein HC, is a low-molecular glycoprotein with immunosuppressive properties.
Its synthesis takes place in liver and lymphocytes. Due to its small molecule size (33,000 Daltons), alpha1-microglobulin is glomerularly filtered and reabsorbed in tubular form. In case of nierein insufficiency the protein accumulates in serum.
In the case of functional disorders of the renal tubules, alpha1-microglobulin is excreted in increased amounts in the urine, which makes damage to the tubules detectable.
General informationThis section has been translated automatically.
In the case of functional disorders of the renal tubules, alpha1-microglobulin is excreted in increased amounts in the urine, which makes the damage to the tubules detectable. The urine concentration of α1-microglobulin is therefore a biomarker of renal function. The urine concentration of alpha1-microglobulin is used as a marker for the detection of tubular damage to the kidney.
Note(s)This section has been translated automatically.
test material: serum, urine
Proteinuria: Identification of tubular disorders
Reference ranges:
- Serum: <5mg/dl
- Urine: <13mg/l
Increased serum levels: reduced glomerular function
Elevated urinary value: marker for tubular proteinuria; e.g. in interstitial nephritis, acute pyelonephritis, toxic damage to the kidneys e.g. after administration of analgesics, cytostatics or aminoglycosides.
LiteratureThis section has been translated automatically.
Neumeister B (2018) Thyroid hormones. In: Neumeister B et al. (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 107-108