Ak against glomerular basement membrane$$$

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Anti-GBM; Goodpasture AK

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DefinitionThis section has been translated automatically.

antibodies directed against type IV collagen of the glomerular basement membrane. Then there are AK that capture other epitopes, or AK against entactin, laminin and other intermediate filaments.

DiagnosisThis section has been translated automatically.

AK detection in serum: A positive ELISA test is the diagnostic criterion.

Immunohistological detection: Typical linear IgG deposits on the basement membrane. Target AG is the C-terminus of the alpha3(IV) chain of type IV collagen in the alveolar and glomerular basement membrane

Differential diagnosisThis section has been translated automatically.

Differential diagnosis of the autoantibody spectrum in pulmonary syndromes

  • Anti-GBM-AK (Goodpasture's syndrome, anti-GBM glomerulonephritis)
  • cANCA /IFT, ELISA (Wegener's granulomatosis, idiopathic RPGN
  • pANCA/IFT,ELISA (microscopic polyarteritis, Churg-Strauss syndrome; idiopathic RPGN
  • Anti-ds-DNA (Lupus erythematosus)
  • Cryoglobulins (Cryoglobulinemia)
  • Without Auto-AK (Purpura Schoenlein-Henoch, Postinfectious Glomerulonephritis

LiteratureThis section has been translated automatically.

  1. Böhm B (2018) Thyroid hormones. In: Neumeister B et al (Eds) Clinical guide to laboratory diagnostics. Elsevier GmbH S. 421-422

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer