Activation-induced deaminase

Activation-induced deaminase" abbreviated AID or AICDA is an RNA-editing deaminase belonging to the family of cytidine deaminases (DNA deaminase), which catalyze the deamination of cytosine residues in single-stranded DNA (Muramatsu M et al. 1999).The coding gene of the same name is located on chromosome 12p13.31.

AICDA is specifically expressed in germinal center-like B cells where it is enzymatically active. Although the activity of AID is essential for antibody diversification, it can be harmful to the organism under certain circumstances, as it can directly induce genomic instability and thus have a mutagenic effect.

Deaminase is involved in somatic hypermutation (SHM), gene conversion and class switch recombination (CSR) in B lymphocytes. For further information see below. ACIDA gene.

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