The gene ABL1 also called "Abelson Murine Leukemia Viral Oncogene Homolog 1" is a protooncogene located on the long arm of chromosome 9 (9q34.1) and has 12 exons. It encodes a tyrosine kinase, which is physiologically involved in various cellular processes. Tyrosine kinase participates in cell division, cell adhesion, cell differentiation and cellular stress response. The tyrosine kinase activity of the gene product can be negatively regulated by its SH3 domain. Deletion of the region encoding the SH3 domain leads to the formation of an oncogene and consequently a constitutively active tyrosine kinase. The DNA-binding activity of the encoded protein is regulated by CDC2-mediated phosphorylation. The ABL1 gene is involved in the development of various leukemias.
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ABL1 Gene
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- de Klein A et al.(1982) A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 300: 765-767
- Knas T (2016) Detection of BCR/ABL1 fusion - Comparative analysis of six commercial probe sets for fluorescence in situ hybridization. Dissertation for the degree of Doctor of Medicine of the Medical Faculty of the University of Ulm, Germany.
- Koretzky GA (2007) The legacy of the Philadelphia chromosome. J Clin Invest 117: 2030-2032