Vitamin d3 analogues
DefinitionThis section has been translated automatically.
Topically active synthetic derivatives of vitamin D. The pharmacological effect in the skin is based on receptor-mediated (vitamin D3 nuclear receptor) transcription and translation modulation, vitamin D3 receptors located in the cell membrane and the regulation of calcium metabolism in keratinocytes and fibroblasts. S.u. Calcipotriol, Tacalcitol, Calcitriol.
Pharmacodynamics (Effect)This section has been translated automatically.
- Inhibition of the cell proliferation of keratinocytes.
- Stimulation of the differentiation of keratinocytes into cornified cells and thickening of the epidermis.
- Immunomodulation by inhibition of the cytokine production of keratinocytes or lymphocytes.
- Increasing the synthesis of cathelicidin LL-37 an antimicrobial peptide.
LiteratureThis section has been translated automatically.
- Gniadecki R (2002) Calcipotriol for erythema annulare centrifugum. Br J Dermatol 146: 317-319
- Kowalzick L (2001) Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis. Br J Dermatol 144: S21-25
- Lamba S, Goodbye M (2001) Combination therapy with vitamin D analogues. Br J Dermatol 144: S27-32
- Lambert J, Trompke C (2002) Tacalcitol ointment for long-term control of chronic plaque psoriasis in dermatological practice. Dermatology 204: 321-324
- Mason J et al (2002) Topical preparations for the treatment of psoriasis: a systematic review. Br J Dermatol 146: 351-364
- Parish JL (2002) Topical vitamin D3 analogues: unapproved uses, dosages, or indications. Clin Dermatol 20: 558-562
- Takahashi H et al (2003) Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation. J Dermatol Sci 31: 21-28