TuberkulidesA18.4

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 03.08.2023

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Synonym(s)

Tuberculid; Tuberculide

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HistoryThis section has been translated automatically.

Darier 1896

DefinitionThis section has been translated automatically.

The term tuberculid is a historical term under which a series of abacterial reactions (so-called"Id reaction"of the skin/now an obsolete term) to tuberculoantigenic material was summarized. The criteria for classification as a tuberculid are still valid today:

  • History or simultaneous manifestation of organ tuberculosis.
  • Typical macro- or micromorphological substrate
  • Strongly positive intracutaneous tuberculin test
  • Healing after antituberculous therapy.

ClassificationThis section has been translated automatically.

The following clinical pictures are assigned to the term "tuberculid" today:

EtiopathogenesisThis section has been translated automatically.

An immunological reaction of the type III immune complex type or type IV late type according to Coombs and Gell is likely. Here, hematogenously scattered antigens of mycobacteria in the skin induce protracted inflammation. Often, these patients are found to have active organ tuberculosis with no anatomic relationship to the tuberculids. Typically, cultural cultures from lesional tissue are negative! Because of the general decline in tuberculosis, further research in this area is nihct.

Clinical featuresThis section has been translated automatically.

LaboratoryThis section has been translated automatically.

Pathogen not culturally detectable.

HistologyThis section has been translated automatically.

Partly tuberculoid granulomas, partly signs of leukocytoclastic vasculitis without pathogen detection.

TherapyThis section has been translated automatically.

In case of detection of tuberculosis, tuberculostatic therapy corresponding to tuberculosis cutis luposa. If necessary, short-term mild creams or ointments containing glucocorticoids externally.

LiteratureThis section has been translated automatically.

  1. Chen Q et al (2019) Cutaneous tuberculosis: A great imitator. Clin Dermatol 37:192-199.
  2. Connors WJ det al.Program-wide review and follow-up of erythema Induratum of Bazin andtuberculosis-associated ocular inflammation management in a TB low-incidencesetting: need for improved treatment candidate selection, therapy standardization, and care collaboration.Infect Dis 19:97.
  3. Darier J (1896) Des tuberculides cutanèes. Ann Derm Syph 7: 1431-1436

  4. Pramatarov K et al (1991) Papulonecrotic tuberculide case report. Z Hautkr 67: 62-64

  5. Thappa DM et al (2003) Tuberculid in a child: transformation from papulonecrotic to lichen scrofulosorum. Pediatric Dermatol 20: 91-93

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Last updated on: 03.08.2023