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Triclosan
Synonym(s)
2% Triclosan cream; Triclosan cream 2%
DefinitionThis section has been translated automatically.
Lipophilic chlorophenol derivative, which is increasingly used as a well-tolerated antiseptic dermatological agent. S.a.u. Antiseptic. Studies suggest that triclosan may cause fibrosis of the liver.
Spectrum of actionThis section has been translated automatically.
Effective against Gram-positive and Gram-negative bacteria. Not effective against Pseudomonas aeruginosa.
IndicationThis section has been translated automatically.
Pyoderma or bacterially superimposed eczema.
Complication(s)This section has been translated automatically.
Triclosan penetrates the skin, especially the lesional skin, so that systemic, undesirable drug reactions are possible when applied over large areas.
Dosage and method of useThis section has been translated automatically.
Apply thinly 1-2 times/day and rub in gently.
Standard concentrationThis section has been translated automatically.
0.1-3% solution; 2% in lipophilic cream base.
Undesirable effectsThis section has been translated automatically.
Allergic contact reactions.
IncompatibilityThis section has been translated automatically.
Interactions of phenolic substances with hydrophilic creams and emulsions are basically possible. As a phenolic agent Triclosan shows incompatibilities with non-ionic surfactants of the polyethylene glycol type.
Notice!
Such incompatibility exists e.g. with Ungt. Cordes.Recipe(s)This section has been translated automatically.
PreparationsThis section has been translated automatically.
Sicorten Plus cream (combination with Halometason), Rutisept extra liquid
Note(s)This section has been translated automatically.
- The 2% hydrophobic Triclosan cream (NRF 11.122) is usually preserved in the pharmacy with potassium sorbate.
- Triclosan has an optimal bactericidal effect at pH 5
- A 1% addition of Triclosan to Advantan cream is possible, the ointment can be kept for 6 weeks after production.
LiteratureThis section has been translated automatically.
- Yang YS et al (2015) Evaluation of toxicity to triclosan in rats following 28 days of exposure to aerosol inhalation. Regul Toxicol Pharmacol 71:259-268