Tobramycin
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
1,5–3 h
Spectrum of actionThis section has been translated automatically.
Branhamella catarrhalis, other s. aminoglycosides.
IndicationThis section has been translated automatically.
Urinary tract infections, severe lower respiratory tract infections, peritonitis, sepsis, bone, joint and soft tissue infections, burns, GIT infections, meningitis.
Dosage and method of useThis section has been translated automatically.
In case of severe infections (depending on infection pattern and kidney function):
- Adults: 3-6 mg/kg bw/day i.m. or i.v.
- School children and infants: 4,5-6 mg/kg bw/day in moderation or in preference
- Infants: 4.5-7.5 mg/kg bw/day or in 2 or 3 days, each in 2-3 days.
- cystic fibrosis: 8-10 mg/kg bw/day i.m. or i.v.
Standard concentrationThis section has been translated automatically.
0.3% as eye drops or eye ointment.
PreparationsThis section has been translated automatically.
Tobramaxin, Gernebcin
Note(s)This section has been translated automatically.
Tobramycin shows a higher efficacy against Pseudomonas aeruginosa than gentamicin.
LiteratureThis section has been translated automatically.
- Baltch AL et al (2007) Antimicrobial Activities of Daptomycin, Vancomycin, and Oxacillin in Human Monocytes and of Daptomycin in Combination with Gentamicin and/or Rifampin in Human Monocytes and in Broth against Staphylococcus aureus. Antimicrobial agents Chemother 51: 1559-1562