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Tiabendazole

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Thiabendazole; Tiabendazole 10%-Betamethasone 01%-Ointment; Tiabendazole ointment 10%

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DefinitionThis section has been translated automatically.

Systemic anthelmintic. Topically it can be applied to Larva migrans.

Tiabendazole is approved in the EU under number E 233 as a food additive (preservative). The substance is only used externally on peels of citrus fruits.

Half-lifeThis section has been translated automatically.

10–12 h

Spectrum of actionThis section has been translated automatically.

Ancylostoma brasiliense, Angiostrongylus cantonensis and costaricensis, Capillaria philippinensis, Dracunculus medinensis, Stronyloides fuelleborni and stercoralis, Toxocara spp.

IndicationThis section has been translated automatically.

Systemic use: Infections with nematodes. Topical use: for Larva migrans.

Dosage and method of useThis section has been translated automatically.

See table

Standard concentrationThis section has been translated automatically.

2-10% in solutions or creams.

Undesirable effectsThis section has been translated automatically.

In case of systemic application: nausea, vomiting, dizziness, hypotension, liver dysfunction, leukopenia, crystalluria, allergic reactions, hallucinations, odour disorders. Very rarely shock, ringing in the ears, erythema exsudativum multiforme.

InteractionsThis section has been translated automatically.

With simultaneous administration of allopurinol or theophylline, increase in xanthine metabolites or theophylline levels.

ContraindicationThis section has been translated automatically.

Pregnancy, liver and kidney failure, hypersensitivity.

Recipe(s)This section has been translated automatically.

Tiabendazole 10%-Betamethasone 0,1%-cream (O/W) R254

Tiabendazole 2% in DMSO solution

R252

PreparationsThis section has been translated automatically.

Mintezol (available through the international pharmacy)

TablesThis section has been translated automatically.

Doses of Tiabendazole for infections with various pathogens

Indication	Dosage
ancylostoma brasiliensis	2 times/day 25 mg/kg bw p.o. over 3 days
angiostrongylus cantonensis	2 times/day 25 mg/kg bw for 7 days
angiostrongylus costaricensis	3 times/day 75 mg/kg bw over 3 days
capillaria philippensis	once/day 25 mg/kg bw for 4 weeks
Dracunculus medinensis	2 times/day 25 mg/kg bw for 3 days
Strongyloides fuelleborni	2 times/day 25 mg/kg bw for 3-5 days
Strongyloides stercoralis	2 times/day 25 mg/kg bw over 3-5 days, possibly up to 3 weeks
Toxocara spp.	2 times/day 25 mg/kg bw for 5-7 days
Trichinella	2 times/day 25 mg/kg bw (max. 3 g/day) over 7 days
Trichostrongylus	2 times/day 25 mg/kg bw for 5 days

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Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer