Terfenadine
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
4–6 h
IndicationThis section has been translated automatically.
Rhinitis allergica, allergic skin reactions.
Limited indicationThis section has been translated automatically.
Bronchial asthma, hypokalemia (previous compensation), known QT time reduction, combination with macrolides or azole antifungals, psoriasis vulgaris (worsening possible).
Dosage and method of useThis section has been translated automatically.
- Adults/teenagers: 2 times/day 60-120 mg p.o.
- Children 9-12 years: 2 times/day 30-60 mg p.o.
- Children 6-9 years: 2 times/day 30 mg p.o.
Undesirable effectsThis section has been translated automatically.
Gastrointestinal disturbances, hyperhidrosis, headache, pruritus, flushing, urticaria, depression, reaction limitation, seizures, fatigue, dizziness, visual disturbances, extrasystoles, cardiac arrhythmias, galactorrhea, bronchospasm, dry mouth, transaminase increase, dysmenorrhea, myalgias, alopecia, photosensitization.
Notice. Discontinue preparation if syncope occurs!
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Hypersensitivity to the active substance, pregnancy, lactation, children < 6 years (Tbl.), children < 12 months (Tbl., suspension), severe liver dysfunction.
PreparationsThis section has been translated automatically.
Hisfedin, Terfenadine ratiopharm
Note(s)This section has been translated automatically.
In the meantime, terfenadine has been withdrawn from the market in various countries due to cardiac side effects. The successor of terfenadine (fexofenadine) is the metabolite of terfenadine responsible for the histamine H1 receptor antagonism. The unfavourable effects on the electrophysiology of the heart are due to the terfenadine mother substance, not to the antihistaminically active metabolite.
LiteratureThis section has been translated automatically.
- del Cuvillo A et al (2006) Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol 16: 3-12
- Borchard U (2003) New H1 antihistamines in comparison. Allergology 1: 23-32
TablesThis section has been translated automatically.
Essential interactions of terfenadine
Clarithromycin |
QT extension |
Erythromycin |
QT prolongation, cardiac arrhythmia, avoid combination |
Fluconazole |
Cardiac arrhythmia |
Fluvoxamine |
torsades de pointes |
Itraconazole |
Cardiac arrhythmia, torsades de pointes, avoid combination |
Josamycin |
QT prolongation, cardiac arrhythmia, avoid combination |
Ketoconazole |
QT prolongation, cardiac arrhythmia, avoid combination |
Miconazole |
Cardiac arrhythmia, avoid combination |
Oleandromycin |
QT prolongation, cardiac arrhythmia |
Roxithromycin |
Cardiac arrhythmia |
Sotalol |
QT extension |
Troleandromycin |
QT extension |