Tat

HIV-1 expressed multifunctional protein with pro-angiogenetic capacity. The Tat peptide is an essential transactivator of HIV-1 and plays a major role in Kaposi's sarcoma. Furthermore, most tat peptides suppress the immune system by modulating the activity of the proteasome. However, tat peptides have also been described that induce angiogenesis but have no effect on the immune system. Such peptides could be used for the therapy of severe peripheral arterial occlusive disease when vascular or endovascular reconstruction is no longer possible.