Steroid 21-hydroxylase autoantibodies

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

21-hydroxylase antibody; NNR antibody; steroid 21-hydroxylase antibody

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DefinitionThis section has been translated automatically.

Antibodies against steroid 21-hydroxylase, which occur mainly in Addison's disease (E27.1) with autoimmune etiology (approx. 80% of cases) and in autoimmune polyendocrinopathies (E31.0) and are of great diagnostic importance for these diseases.

General informationThis section has been translated automatically.

The antibody titers show no correlation to the course of the disease.

Note(s)This section has been translated automatically.

If NNR antibodies are present, additional tests for marker antibodies (e.g. against thyroid, parathyroid, pancreas, and other organ-specific antibodies) may be indicated. Determination from serum, EDTA or heparin plasma.

LiteratureThis section has been translated automatically.

  1. Bansal S et al (2015) Presence of 21-hydroxylase Antibodies in a Boy with X-Linked Adrenal Hypoplasia Congenita. Horm Res Paediatr 84:408-413.
  2. Dörr HG et al (2018) Mortality in children with classic congenital adrenal hyperplasia and 21-hydroxylase deficiency (CAH) in Germany. BMC Endocr Disord 18:37.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer