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- Bright spots are caused by a congenital or acquired, circumscribed or generalized melanin deficiency or complete melanin loss of the skin (loss or dysfunction of melanocytes).
- If depigmentations occur as temporary, circumscribed, secondary during or in the wake of skin diseases (intra- and/or perilesional), they are called leukoderms.
- Pseudoleukoderms are skin lesions that are a negative imprint of normally colored skin light against a dark environment. Bright spots are also caused by circumscribed reduced blood circulation, e.g. naevus anaemicus or Raynaud's phenomenon, dermographism albus.