SLURP1 Gene

The SLURP1 gene (SLURP1 is the acronym for: Secreted LY6/PLAUR Domain Containing 1) is a protein coding gene
locatedon chromosome8q24
.3. The protein encoded by SLURP1 is a member of the Ly6/uPAR family. SLURP1 is located in the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.

Mutations in this gene are associated with keratosis palmoplantaris transgrediens et progrediens with mutations in SLURP1 (Mal de Meleda), a rare autosomal recessive skin disease.

The SLURP1 protein can be addressed as an epidermal neuromodulator that is important for epidermal homeostasis and inhibition of TNF-alpha release from macrophages, leading to hyperproliferation and inflammatory skin changes. Furthermore, SLURP1 protein possesses antitumor activity. SLURP-1 was found to be a marker of late skin differentiation and is involved in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro, it downregulates keratinocyte proliferation. Furthermore, in T cells, SLURP1 protein is involved in the regulation of intracellular Ca(2+) signaling. It appears to exert an immunomodulatory function in the surface epithelium. SLURP1 is also detected in various biological fluids such as sweat, saliva, tears and urine from normal subjects (Favre B et al. 2007).

1. Favre B et al. (2007) SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda. J Invest Dermatol 127:301-308.