Saquinavir
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
10 h
Pharmacodynamics (Effect)This section has been translated automatically.
HIV protease inhibitor.
IndicationThis section has been translated automatically.
Combination therapy of HIV infection.
Dosage and method of useThis section has been translated automatically.
Invirase: Adults and children > 16 years: 2 times/day 1000 mg (2 times 5 hard caps.) plus ritonavir 100 mg 2 times/day.
Notice! Saquinavir must be taken in the first 2 hours after a meal. Grapefruit juice increases the bioavailability of saquinavir by 40% if 150 ml is taken at the beginning of a meal and one hour later!
Undesirable effectsThis section has been translated automatically.
Nausea, abdominal pain, fever, headache, weakness.
InteractionsThis section has been translated automatically.
See Table 1.
PreparationsThis section has been translated automatically.
Invirase
LiteratureThis section has been translated automatically.
- Eron JJ JR (2002) HIV-1 protease inhibitors. Clin Infect Dis 30: 160-170
TablesThis section has been translated automatically.
Key interactions of saquinavir
Clindamycin |
Clindamycin plasma levels ↑ |
Dapson |
Dapson plasma mirror ↑ |
Itraconazole |
Saquinavir plasma mirror ↑ |
Ketoconazole |
Saquinavir plasma mirror ↑ |
Phenytoin |
Saquinavir plasma mirror ↓ |
Rifabutin |
Saquinavir plasma mirror by 40% ↓ |
Rifampicin |
Saquinavir plasma mirror by 40% ↓ |