Retapamulin
Synonym(s)
Retapamulinum
DefinitionThis section has been translated automatically.
Antibiotic from the pleuromutiline group.
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of protein synthesis by binding to the 50s subunit of the 70s ribosomes of bacteria.
Spectrum of actionThis section has been translated automatically.
Retapamulin has a bacteriostatic effect against Staphylococcus aureus and Streptococcus pyogenes by inhibiting bacterial protein synthesis via ribosomal binding. The binding site is different from other antibiotics. It is not effective against Gram-negative bacteria (e.g. Escherichia coli and Haemophilus influenzae).
IndicationThis section has been translated automatically.
Approved for topical treatment of impetigo and other skin infections from the age of 9 months.
Dosage and method of useThis section has been translated automatically.
Cream 1%: Apply 2 times/day, use for 5 days
Standard concentrationThis section has been translated automatically.
1% cream
PreparationsThis section has been translated automatically.
Altargo®
LiteratureThis section has been translated automatically.
- Rittenhouse S et al (2006) Selection of retapamulin, a novel pleuromutilin for topical use. Antimicrob Agents Chemother 50: 3882-3885