Subtype of chronic prurigo of a very rare, chronic, polyetiological systemic disease characterized by numerous, large, violently itching (or also painful) plaques and nodules, which is regarded as the maximum form of prurigo simplex subacuta (or nodular variant of lichen simplex chronicus) (remark: many authors emphasize the etiogenetic independence of prurigo nodularis). Characteristic for this disease is an almost unbreakable cycle of itching/pain, uncontrollable scratching. From lesional scratching effects with reactive skin changes (inflammation, acanthosis, fibrosis, increased density of substance P-positive nerves) and a again flaring itching/pain (Tsianakas A et al. 2016).
For more details on prurigo of the nodular type (prurigo nodularis), see below. Prurigo chronic.