Propranolol gel 1%, 20g
Note: These manufacturing instructions have been prepared by the pharmacy of the University Hospital Heidelberg and have
beenspecially developed for the patients of the University Hospital.
It serves as an aid for public pharmacies in the preparation of prescriptions. However, this does not release the pharmacy from the
obligations imposed by ApBetrO (e.g. plausibility checks, documentation, etc.).
1) According to NRF S.18, a benzalkonium chloride solution containing edetate 0.1% is prepared:
- Benzalkonium chloride 50% 0,2 g
- Sodium EDTA 1,0 g
- Purified water 98,8g
2. a preserved natrosol gel is produced as the basis for the formulation:
- Natrosol 250G (hydroxyethyl cellulose) 7.2 g
- Edetath. Benzalkonium chloride solution 0.1% 10.0g
- purified water 82,8 g
Water and benzalkonium chloride solution are mixed in an Unguator or Topitec jug
. Natrosol is sprinkled, stirred, allowed to swell and homogenized with the stirrer
. If necessary, allow the gel to swell overnight and stir again the next day
.
3. preparation of the propranolol gel:
- Propranolol hydrochloride is weighed on the analytical balance and placed in a fanta dish.
- Natrosol gel is added in proportions and the powder is incorporated and dissolved.
- If necessary, leave the mixture to stand for a while to dissolve the powder completely.
- Fill the gel and label it.
Organoleptic test: A clear, homogeneous gel is formed in which propranolol-HCl is dissolved.
Shelf life: 3 months at 2-8°CPacking agent
: aluminium tube
Application: superficial hemangiomas
Sources: The formula is based on a proprietary development of the pharmacy of the University Hospital of Heidelberg. The stability of the active ingredient was determined by UV/Vis spectrometry over 3 months. 6/2015