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PorocarcinomaC44.L

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 02.03.2022

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Synonym(s)

Carcinoma eccrine epidermotropic; Carcinoma epidermotropic eccrine; dysplastic poroma; Epidermotropic eccrine carcinoma; Hidroacanthoma simplex maligna; malignant eccrine poroma; malignant syringoacanthoma; Porom dysplastic; Porom malignes eccrines; syringoacanthoma malignes

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HistoryThis section has been translated automatically.

Pinkus and Mehregan, 1963

DefinitionThis section has been translated automatically.

Rare, malignant, infiltrating sweat gland tumor originating from the intraepidermal part of the eccrine sweat gland excretory duct. Retrograde ingrowth into the epidermis is characteristic.

Occurrence/EpidemiologyThis section has been translated automatically.

Incidence: 0.01-0.005%.

ManifestationThis section has been translated automatically.

Mostly in the older age beyond 50 LJ (average age at manifestation 60-70 years).

LocalizationThis section has been translated automatically.

Ears, hands, face and capillitium; more rarely in the genital area.

Clinical featuresThis section has been translated automatically.

Slow-growing, plate-like or nodular tumors with ulcerations. In terms of appearance, size and localization, the tumors are highly variable. Frequently, they arise on the floor of a poroma that has existed for years. Clinical malignancy criterion is a sudden rapid growth of the preexisting tumor. Porocarcinomas may also develop in a nevus sebaceus.

Lymphogenic metastasis is possible (12% of cases), as is seeding of epidermotropic metastases. Rarely, visceral metastases develop.

HistologyThis section has been translated automatically.

Often arising at the base of a poroma, asymmetric carcinoma that broadly infiltrates the deeper portions of the dermis (and subcutis). Tumor formations with reticularly branched, ribbon-like structures that make broad-based contact with the surface epithelium are characteristic. As in poroma, the formation of ductal as well as light cell structures is possible. Cell formations of small basaloid cells with chromatin-rich nuclei are seen. Abundant mitoses. Evidence of mass necrosis (see also under poroma).

The intraepithelial form of porocarcinoma is called malignant hidroacanthoma simplex. It is characterized by poroid epithelial clusters with densely packed tumor cells, numerous mitoses, and a markedly increased proliferation rate.

Differential diagnosisThis section has been translated automatically.

Poroma; seborrheic keratosis; spinocellular carcinomas; Merkel cell carcinomas; cutaneous lymphomas; amelanotic melanomas.

TherapyThis section has been translated automatically.

Procedure as for spinocellular carcinoma. Radical excision with histological edge control. Safety distance of at least 1 cm. In case of lymph node or organ metastases: Procedure as in spinocellular carcinoma.

Progression/forecastThis section has been translated automatically.

Slow growth. Lethal outcome is possible. In the presence of lymph node metastases the lethality rate is over 65%.

LiteratureThis section has been translated automatically.

  1. Gartmann H (1985) Eccrine porocarcinoma. Z Hautkr 60: 555-562
  2. Grayson W et al (2003) Eccrine porocarcinoma of the penis. J Urol 169: 611-612
  3. Gu LH et al (2003) Aberrant expression of p16 and RB protein in eccrine porocarcinoma. J Cutan cathode 29: 473-479
  4. Helmer A et al (2006) Eccrine porocarcinoma in addition to multiple other epithelial skin tumors. Dermatologist 57: 1120-1121
  5. Horn T et al (1985) Malignant eccrine poroma. Z Hautkr 60: 992-999
  6. Johr R et al (2003) Eccrine porocarcinoma arising in a seborrheic keratosis evaluated with dermoscopy and treated with Mohs' technique. Int J Dermatol 42: 653-657
  7. Murphy LA; Barlow RJ (2003) Eccrine porocarcinoma treated with Moh`s micrographic surgery: a report of three cases. Br J Dermatol 149 (Suppl 64): 103
  8. Pinkus H, Mehregan AH (1963) Epidermotrophic eccrine carcinoma: a case combining features of eccrine poroma and Paget's dermatosis. Arch Dermatol 88: 597-606
  9. Shaw M et al (1982) Malignant eccrine poroma: a study of twenty-seven cases. Br J Dermatol 107: 675-680
  10. Snow SN et al (1992) Eccrine porocarcinoma of the face. J Am Acad Dermatol 27: 306-311

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Last updated on: 02.03.2022

Author: Prof. Dr. med. Peter Altmeyer