Rare, mostly highly differentiated spinocellular carcinoma of the penis with varying cornification tendency.
Images (6)
Penile carcinomaC60.-
DefinitionThis section has been translated automatically.
Occurrence/EpidemiologyThis section has been translated automatically.
In Europe, the incidence is estimated at 0.1-0.9/100,000 men.
EtiopathogenesisThis section has been translated automatically.
Favouring factors: phimosis (smegma influence); early sexual activity; long term HPV history (recurrent condyloma acuminata); lichen sclerosus et atrophicus.
ManifestationThis section has been translated automatically.
4th to 7th decade of life.
LocalizationThis section has been translated automatically.
Mainly dorsal side of the glans penis, sulcus coronarius, prepuce.
Clinical featuresThis section has been translated automatically.
Primarily, slow-growing, usually sharply demarcated, irregularly configured, verrucous plaques are seen. Larger tumors (> 0.5 cm) are characterized by rough indurated, irregularly configured, usually ulcerated disintegrating plaques or nodules that bleed easily on mechanical irritation. Penile carcinomas tend to metastasize early to the regional lymph nodes.
Differential diagnosisThis section has been translated automatically.
Syphilitic primary effect; see below Syphilis acquisita.
TherapyThis section has been translated automatically.
- Small tumours (up to about the size of a lens):
excision with a small safety distance, additionally circumcision for terrain rehabilitation. - Larger tumours: excision of the tumour by urologists, possibly partial penile amputation. If necessary, additional radiotherapy including the regional lymph node stations (see carcinoma, spinocellular).
- Very large tumours with metastasis in the regional lymph nodes: penis amputation and extirpation of the inguinal and iliac lymph nodes and follow-up radiation (see carcinoma, spinocellular).
- If distant metastasis has already occurred: maximum possible surgical reduction of the tumour mass and subsequent chemotherapy (cisplatin, bleomycin, 5-fluoracil).
Progression/forecastThis section has been translated automatically.
The 5-year survival rate for lymph node metastasis depends on the extent of the tumor. In case of unilateral LK infestation 52% of patients survive 5 years, in case of bilateral LK infestation only 27%.