The pancreatitis-panniculitis-polyarthritis syndrome (PPP syndrome) is a clinical symptom complex that occurs in patients with pancreatitis (or an acinar-endocrine carcinoma of the pancreas), with (pancreatic) aseptic panniculitis and polyarthritis (sometimes with osteonecrosis of varying severity). The cause lies in the (massive) release of pancreatic enzymes such as trypsin, lipase and amylase, which leads to aseptic necrosis in the fatty tissue far from the heart.
Pancreatitis, polyarthritis and panniculitis syndrome
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